MEN1
Germline (hereditary) and somatic mutation
Roles in cell function
- Encodes for menin protein that regulates gene transcription, genomic stability, cell proliferation and apoptosis
- Menin interacts with β-catenin, another protein that regulates gene transcription, whose dysregulation leads to tumor development, including endocrine tumors
Types of cancers linked with MEN1 mutation
- Pancreatic islet cell tumors (gastrinomas, insulinomas, glucagonomas, vasoactive intestinal polypeptidomas, pancreatic polypeptidomas)
- Pituitary tumors
- Bronchial carcinoid
- Gastrointestinal (GI) neuroendocrine tumor
- Thymic neuroendocrine tumor