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MEN1

Written by J. GuanJan 2, 20241 min read
Cancer DNA

Germline (hereditary) and somatic mutation

Roles in cell function

  • Encodes for menin protein that regulates gene transcription, genomic stability, cell proliferation and apoptosis
  • Menin interacts with β-catenin, another protein that regulates gene transcription, whose dysregulation leads to tumor development, including endocrine tumors

Types of cancers linked with MEN1 mutation

  • Pancreatic islet cell tumors (gastrinomas, insulinomas, glucagonomas, vasoactive intestinal polypeptidomas, pancreatic polypeptidomas)
  • Pituitary tumors
  • Bronchial carcinoid
  • Gastrointestinal (GI) neuroendocrine tumor
  • Thymic neuroendocrine tumor
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