ROS1
Roles in cell function
- Spans the width of the cell membrane to receive external stimuli and transmit the signal into the cells
- Signal internalized by ROS1 is further passed on through signalling pathways to trigger cell growth and maturation (differentiation into cells with specific functions)
- Cells with mutated ROS1 are constantly being activated and grow without control to form cancerous tumors.
Types of cancer linked to mutation
- Non-small cell lung cancer (NSCLC)
- Gastric cancer
- Colorectal cancer
- Ovarian cancer
- Bile duct cancer (cholangiocarcinoma)
- Glioblastoma
- Angiosarcoma
Related: ROS1-positive lung cancer